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Fauci on 'Highly Specific, Direct' Therapy for COVID-19
— Can monoclonal antibodies duplicate the success with Ebola in COVID-19?

by Molly Walker, Associate Editor, MedPage Today
August 28, 2020

"There's a lot of activity and it's a highly concentrated, highly specific, direct antiviral approach to a number of diseases. The success in Ebola was very encouraging," said National Institute of Allergy and Infectious Diseases (NIAID) Director Anthony Fauci, MD.

Most recently thrust into the spotlight as effective treatments for Ebola, monoclonal antibodies are currently being researched as a potential treatment for HIV, as well as COVID-19. This month, the NIH highlighted trials of monoclonal antibodies being conducted among several different COVID-19 patient populations: outpatients with COVID-19, patients hospitalized with the disease, and even a trial in household contacts of confirmed cases, where the therapy was used as prophylaxis.

Fauci explained how the mechanism of monoclonal antibodies "is really one of a direct antiviral."

"It's like getting a neutralizing antibody that's highly, highly concentrated and highly, highly specific. So, the mechanism involved is blocking of the virus from essentially entering its target cell in the body and essentially interrupting the course of infection," he said.

While Fauci noted the success of monoclonal antibodies to treat Ebola, he added that they are not practical for other viruses that only last a day or two, where the virus may already be cleared once the patient receives the treatment."If you have a disease that's serious enough and prolonged enough, such as what we saw with Ebola, and what we are currently seeing with COVID-19, then you have enough opportunities to get the monoclonal antibody to actually work," he added.

Monoclonal antibodies are currently being administered intravenously, though Fauci said if the treatment works, "you try to get it to a form where you can give it subcutaneously or intramuscularly," a much more convenient way of administering the therapy.

He also explained the difference between monoclonal antibodies and convalescent plasma, describing them as "extremely pure," due to their homogeneous nature. Therefore the recent published side effects seen in trials of convalescent plasma in COVID-19 patients may not apply.

"The difference between monoclonal antibodies and convalescent plasma is plasma has a lot of other things in it, which could lead to allergic and other reactions," Fauci said. "Theoretically, there are more complex factors in plasma than there are with a monoclonal antibody."

Ultimately, when asked if one of his patients asked him about monoclonal antibodies, Fauci said he would say they are a "promising form of therapy."
"Many of them are still in clinical trials and not available for routine use, but the data that has accumulated recently indicates they are a very promising form of prevention and treatment," he noted

In Luce tua Videmus Lucem KRK
Oh come on. Some positive tests don't have the virus?

I gotta read this one again later.

  • KRK
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Wait.....what are you saying.....that the government would mislead us?

“It's easier to fool people than to convince them that they have been fooled.” attributed to Mark Twain
In Luce tua Videmus Lucem KRK
If you're interested, here's the report from CDC  that seems to have people in a raucous.

"For 6% of the deaths, COVID-19 was the only cause mentioned."
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CDC changed how they display everything and now the positive tests number took a major jump. But it looks like the death rate is going down.
 image.png You have insufficient rights to see the content.

The column on the far right shows that age group plus the older age groups. So, 45-54 years and older account for 97.02% of the COVID-19 related deaths.
 image.png You have insufficient rights to see the content.

Just Wisconsin. 8 Males and 13 Females are not accounted for in this chart because they did not have their age available or did not provide it or ... no idea.
 image.png You have insufficient rights to see the content.
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Could Boosting Vitamin D Cut COVID-19 Risk?
— Observational study suggests there may be a link between the two
by Molly Walker, Associate Editor, MedPage Today September 3, 2020

Patients with "likely deficient" vitamin D status had nearly doubled risk of testing positive for COVID-19 versus those with "likely sufficient" vitamin D, a single-center study found.

Among nearly 500 patients, the relative risk for infection was 1.77 (95% CI 1.12-2.81, P=0.02) in those judged to be vitamin D-deficient (below 20 ng/mL or 18 pg/mL, respectively) compared with patients believed to have sufficient vitamin D, reported David Meltzer, MD, PhD, of the University of Chicago, and colleagues writing in JAMA Network Open.

Deficiency and sufficiency were estimated not only on the basis of vitamin D metabolite levels (25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol with thresholds of 20 ng/dL and 18 pg/mL, respectively) but also on records of vitamin D supplement prescriptions following those measurements.

The authors acknowledged one major caveat, however: vitamin D deficiency may be associated with many other COVID-19 risk factors, including age, obesity, diabetes, and chronic illness. Their statistical analysis included adjustments for many of these, but potential remained for residual confounding.

"[O]bserved associations of vitamin D with outcomes in almost any observational study may fail to accurately reflect any potential causal effects of vitamin D on outcomes," they cautioned.

The authors pointed to prior research suggesting a link between vitamin D and a decrease in other viral respiratory infections, and also noted vitamin D deficiency is "common." In particular, they cited the potential of shelter-in-place orders to decrease sun exposure, augmenting the need for vitamin D supplementation.

"To our knowledge, this study provides the first assessment of the association of vitamin D deficiency and potentially insufficient treatment with testing positive for COVID-19," they wrote.

Meltzer and colleagues drew on electronic health record data from 4,314 patients tested for COVID-19 at their institution from March 3 to April 10. Of these, 489 had complete data and were included in the sample. Average patient age was 49, 75% were women, and almost 70% were nonwhite (primarily Black).

One-quarter were determined to be likely deficient in vitamin D and 59% were likely sufficient; the remainder didn't qualify for either status because supplement prescriptions after measurement introduced uncertainty.

Compared to patients who weren't vitamin D deficient, those who were tended to be younger, a race other than white, more likely to receive vitamin D2 and less likely to receive vitamin D3.

Overall, 71 participants tested positive for COVID-19.

Other than vitamin D deficiency being a consequence of chronic health conditions or behavioral factors that increase COVID-19 risk, limitations to the data also include its limited sample size and that researchers were limited to data within the electronic health record.

Meltzer and colleagues suggested that interventions to reduce vitamin D deficiency, as a means to reduce COVID-19 risk, be tested in randomized trials. Such research would be especially pertinent since both African-American and Hispanic populations not only have disproportionate morbidity and mortality from COVID-19, but also high rates of vitamin D deficiency.
In Luce tua Videmus Lucem KRK
Lovely, just freaking lovely. My youngest is now gonna have to be home schooled and we don't have any parent who can stay home from work to help her.
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And this is why we are closing schools?!?!?!?...hmmmm, why do you think that is ??? There couldn't be any politics involved...could there!?!?!?

Don't worry Z2C, schools will be open the day after the election.


*The best estimate representative of the point estimates of R0 from the following sources:
Chinazzi M, Davis JT, Ajelli M, et al. The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science. 2020;368(6489):395-400; Imai N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C. A., Riley, S., Ferguson, N.M. (2020). Report 3: Transmissibility of 2019-nCoV. Online report
Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-1207
Munayco CV, Tariq A, Rothenberg R, et al. Early transmission dynamics of COVID-19 in a southern hemisphere setting: Lima-Peru: February 29th-March 30th, 2020 [published online ahead of print, 2020 May 12]. Infect Dis Model. 2020; 5:338-345
Salje H, Tran Kiem C, Lefrancq N, et al. Estimating the burden of SARS-CoV-2 in France [published online ahead of print, 2020 May 13] [published correction appears in Science. 2020 Jun 26;368(6498):]. Science. 2020;eabc3517.
The range of estimates for Scenarios 1-4 represent the upper and lower bound of the widest confidence interval estimates reported in: Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-1207.
Substantial uncertainty remains around the R0 estimate. Notably, Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R. High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. 2020;26(7):1470-1477 (https://dx.doi.org/10.3201/eid2607.200282external icon) estimated a median R0 value of 5.7 in Wuhan, China. In an analysis of 8 Europe countries and the US, the same group estimated R0 of between 4.0 and 7.1 in the pre-print manuscript: Ke R., Sanche S., Romero-Severson, & E., Hengartner, N. (2020). Fast spread of COVID-19 in Europe and the US suggests the necessity of early, strong and comprehensive interventions. medRxiv.
In Luce tua Videmus Lucem KRK
Originally Posted by: KRK 

And this is why we are closing schools?!?!?!?...hmmmm, why do you think that is ??? There couldn't be any politics involved...could there!?!?!?

Don't worry Z2C, schools will be open the day after the election.

I'm sure there are politics involved. And if we didn't have Social Media, I'm willing to bet the political side of it wouldn't be nearly as impactful. As for schools opening up the day after the election, I doubt that. I think there are going to be so many write-ins or absentee ballets (whatever they are called) that it'll take weeks, if not over a month to decide who won the election.

I really am hating the loud squeaky wheel crowd. I'm trying to be open minded, but it's just not working. I'm getting filled with anger more and more everyday over this.
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Also, as a follow-up to the HCQ discussions...

Many countries either adopted or declined early treatment with HCQ, effectively forming a large trial with 1.8 billion people in the treatment group and 663 million in the control group. As of September 20, 2020, an average of 70.1 per million in the treatment group have died, and 477.2 per million in the control group, relative risk 0.147. After adjustments, treatment and control deaths become 146.8 per million and 715.0 per million, relative risk 0.21. The probability of an equal or lower relative risk occurring from random group assignments is 0.015. Accounting for predicted changes in spread, we estimate a relative risk of 0.26. The treatment group has a 73.9% lower death rate. Confounding factors affect this estimate. We examined diabetes, obesity, hypertension, life expectancy, population density, urbanization, testing level, and intervention level, which do not account for the effect observed.
In Luce tua Videmus Lucem KRK
That’s the problem. The election should be over and decided by the day after.
If you don’t get your ballot in by 8pm Election Day, it should not count.
Laziness shouldn’t be an excuse.
I and my wife already took care of it. There’s no excuse for people not to get it done.
And the virus is being used by the Democrats to blame the President like somehow it’s his fault.
Like I said before, Trump was called a racist when he shut down incoming flights from China. Then they scream he didn’t act fast enough.
Which is it?
I know....which ever they can try to use against him at the time.
I’m sure that right after the election, a lot of the virus problems will disappear. (At least in the “official numbers”) unless of course Trump wins re-election.
UW La Crosse just cancelled spring break. As a parent of a pretty little blond girl, I'm good with this! I don't need my kid trying to do Girls Gone Wild kinda shit!!!

Here's some alleged Masks facts.
Originally Posted by: Zero2Cool 

UW La Crosse just cancelled spring break. As a parent of a pretty little blond girl, I'm good with this! I don't need my kid trying to do Girls Gone Wild kinda shit!!!

Here's some alleged Masks facts.

So....how does Dad know about “Girls Gone Wild”???🤪😂
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Nine Covid Facts: A Pandemic of Fearmongering and Ignorance

written by jeff harris wednesday october 28, 2020


Ever since the alleged pandemic erupted this past March the mainstream media has spewed a non-stop stream of misinformation that appears to be laser focused on generating maximum fear among the citizenry. But the facts and the science simply don’t support the grave picture painted of a deadly virus sweeping the land.

Yes we do have a pandemic, but it’ a pandemic of ginned up pseudo-science masquerading as unbiased fact. Here are nine facts backed up with data, in many cases from the CDC itself that paints a very different picture from the fear and dread being relentlessly drummed into the brains of unsuspecting citizens.

1) The PCR test is practically useless

According to an article in the New York Times August 29th 2020 testing for the Covid-19 virus using the popular PCR method results in up to 90% of those tested showing positive results that are grossly misleading.

Officials in Massachusetts, New York and Nevada compiled testing data that revealed the PCR test can NOT determine the amount of virus in a sample. (viral load) The amount of virus in up to 90% of positive results turned out to be so miniscule that the patient was asymptomatic and posed no threat to others. So the positive Covid-19 tests are virtually meaningless.

2) A positive test is NOT a CASE

For some reason every positive Covid-19 test is immediately designated a CASE. As we saw in #1 above up to 90% of positive Covid-19 tests result in miniscule amounts of virus that do not sicken the subject. Historically only patients who demonstrated actual symptoms of an illness were considered a case. Publishing positive test results as “CASES” is grossly misleading and needlessly alarming.

3) The Centers for Disease Control dramatically lowered the Covid-19 Death Count

On August 30th the CDC released new data that showed only 6% of the deaths previously attributed to Covid-19 were due exclusively to the virus. The vast majority, 94%, may have had exposure to Covid-19 but also had preexisting illnesses like heart disease, obesity, hypertension, cancer and various respiratory illnesses. While they died with Covid-19 they did NOT die exclusively from Covid-19.

4) CDC reports Covid-19 Survival Rate over 99%

The CDC updated their “Current Best Estimate” for Covid-19 survival on September 10th showing that over 99% of people exposed to the virus survived. Another way to say this is that less than 1% of the exposures are potentially life threatening. According to the CDC the vast majority of deaths attributed to Covid-19 were concentrated in the population over age 70, close to normal life expectancy.

5) CDC reveals 85% of Positive Covid cases wore face masks Always or Often

In September of 2020 the CDC released the results of a study conducted in July where they discovered that 85% of the positive Covid test subjects reported wearing a cloth face mask always or often for two weeks prior to testing positive. The majority, 71% of the test subjects reported always wearing a cloth face mask and 14% reported often wearing a cloth face mask. The only rational conclusion from this study is that cloth face masks offer little if any protection from Covid-19 infection.

6) There are inexpensive, proven therapies for Covid-19

Harvey Risch, MD, PhD heads the Yale University School of Epidemiology. He authored “The Key to Defeating Covid-19 Already Exists. We Need to Start Using It” which was published in Newsweek Magazine July 23rd, 2020. Dr. Risch documents the proven effectiveness of treating patients diagnosed with Covid-19 using a combination of Hydroxychloroquine, an antibiotic like azithromycin and the nutritional supplement zinc. Medical Doctors across the globe have reported very positive results using this protocol particularly for early stage Covid patients.

7) The US Death Rate is NOT spiking

If Covid-19 was the lethal killer it’s made out to be one would reasonably expect to see a significant spike in the number of deaths reported. But that hasn’t happened. According to the CDC as of early May 2020 the total number of deaths in the US was 944,251 from January 1 – April 30th. This is actually slightly lower than the number of deaths during the same period in 2017 when 946,067 total deaths were reported.

8) Most Covid-19 Deaths Occur at the End of a normal Lifespan

According to the CDC as of 2017 US males can expect a normal lifespan of 76.1 years and females 81.1 years. A little over 80% of the suspected Covid-19 deaths have occurred in people over age 65. According to a June 28th New York Post article almost half of all Covid suspected deaths have occurred in Nursing Homes which predominately house people with preexisting health conditions and close to or past their normal life expectancy.

9) CDC Data Shows Minimal Covid Risk to Children and Young Adults

The CDC reported in their September 10th update that it’s estimated Infection Mortality Rate (IFR) for children age 0-19 was so low that 99.97% of those infected with the virus survived. For 20-49 year-olds the survival rate was almost as good at 99.98%. Even those 70 years-old and older had a survival rate of 94.6%. To put this in perspective the CDC data suggest that a child or young adult up to age 19 has a greater chance of death from some type of accident than they do from Covid-19.

Taken together it should be obvious that Covid-19 is pretty similar to typical flu viruses that sicken some people annually. The vast majority are able to successfully fight off the virus with their body’s natural immune system. Common sense precautions should be taken, particularly by those over age 65 that suffer from preexisting medical conditions.

The gross over reaction by government leaders to this illness is causing much more distress, physical, emotional and financial, than the virus ever could on its own. The bottom line is there is NO pandemic, just a typical flu season that has been wildly blown out of proportion by 24/7 media propaganda and enabled by the masses paralyzed by irrational fear.

State and local governments in particular have ignored the rights of the people and have instituted outrageous attacks on freedom and liberty that was bought and paid for by the blood and sacrifice of our forefathers.

Slowly the people are recognizing the great fraud perpetrated on them by bureaucrats and elected officials who have sworn to uphold rights and freedoms as spelled out in the US Constitution. The time has come to hold these criminals accountable by utilizing the legal system to bring them to justice.

Either we act now to preserve freedom and liberty for our children and future generations yet unborn, or we meekly submit to tyrants who crave more power and control. I will not comply!

In Luce tua Videmus Lucem KRK
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Sorry if I goofed up the pics

These 12 Graphs Show Mask Mandates Do Nothing To Stop COVID
No matter how strictly mask laws are enforced nor the level of mask compliance the population follows, cases all fall and rise around the same time.

Yinon Weiss OCTOBER 29, 2020


Masks have become a political tool and a talisman. When COVID-19 hit, governments panicked and created enormous fear. The Centers for Disease Control currently estimates a COVID-19 survival rate of 99.99 percent for people younger than 50, but the damage created by the panic was too great to undo.

It is likely that some politicians eventually realized their mistake and needed a way to back-pedal without admitting their lockdowns were a policy disaster. Their solution was for people to put any old piece of cloth across their face and magically believe that it’s okay to go out shopping again.

Masks are not merely a small inconvenience. They have inadvertently become a key impediment to returning to a more normal life, a desirable goal for
those seeking to twist the pandemic for political and electoral purposes.

Masks dehumanize us, and ironically serve as a constant reminder that we should be afraid. People can now be spotted wearing masks while camping by themselves in the woods or on a solo sailing trip. They have become a cruel device on young children everywhere, kindergarten students covered by masks and isolated by Plexiglas, struggling to understand the social expressions of their peers. Face coverings are causing real harm to the American psyche, provide little to no medical benefit, and distract us from more important health policy issues.

The mask dogma had many cracks in it from the start. For one, the U.S. surgeon general and the Centers for Disease Control both previously said that “masks are NOT effective in preventing [the] general public from catching coronavirus,” so they were already starting with a credibility deficit.

Furthermore, many officials have been frequently caught without masks when they think the cameras are off them. Dr. Anthony Fauci, for example, has been caught doing this multiple times.

Chicago’s mayor and local media were all caught taking off their masks and violating social distancing as soon as a press conference ended. This was caught in a now deleted YouTube video that was shared by a now deleted Twitter account after being retweeted more than 26,000 times. As of the date of this publication, it is still available to view in a crude video of a video that has yet to be deleted on YouTube.

Clearly, some people do not want you to see what politicians do behind the scenes. Pennsylvania Gov. Tom Wolf, a strong advocate for mandatory masking, was caught off camera laughing about how wearing masks is an act of “political theater.”

Faking ‘Science’ to Achieve Political Goals

These same politicians and health officials are so desperate to make people believe in masks that they doctor charts to make their case, even when their own data actually undermines them. So what is the actual science behind masks? Let’s begin by reviewing the leading scientific studies.

The Centre for Evidence-Based Medicine at Oxford University summarized six international studies which “showed that masks alone have no significant effect in interrupting the spread of ILI or influenza in the general population, nor in healthcare workers.” Oxford went on to say that “that despite two decades of pandemic preparedness, there is considerable uncertainty as to the value of wearing masks.” They prophetically warned that this has “left the field wide open for the play of opinions, radical views and political influence.”

A study of health-care workers in more than 1,600 hospitals showed that cloth masks only filtered out 3 percent of particles. An article in the New England Journal of Medicine stated, “[W]earing a mask outside health care facilities offers little, if any, protection from infection” and that “[T]he desire for widespread masking is a reflexive reaction to anxiety over the pandemic.”

There are many other credible studies showing lack of mask efficacy, such as studies published in the National Center for Biotechnology Information, Cambridge University Press, Oxford Clinical Infectious Diseases, and Influenza Journal, just to name a few.

Studies do show masks can help in the case of direct respiratory droplets, which would matter if somebody is coughing, breathing, or sneezing directly on your face. That happens normally in a tight and highly confined space.

But the plentiful evidence we have indicates masks would not meaningfully help with aerosol transmission, where two people are just in the same area, or even the same room. This is because the two people end up breathing the same air, with or without a mask, as visually demonstrated in this video.

Now for Graphs about International Mask Mandates

Historical scientific studies do not make a compelling case that universal masking would meaningfully help, so let’s explore real-world situations to see where data leads us.

Austria was one of the first governments to require masks, and it did so about 10 days after its cases began to go down. The level of downtrend did not change or improve after masks were required. After the nation’s people wearing masks for an extended period, cases are currently four times where they were when Austria mandated masks, and cases continue to climb.

Germany mandated masks about halfway down its original recovery. Their cases are now similarly climbing quickly.

The French now have around 1,000 percent more daily cases they had when they mandated masks, despite having one of the highest mask compliance levels in the world.

Spain was not far behind its French neighbor with a mandate. Spain required masks when cases were near zero and has the highest compliance with mask-wearing in all Europe. Now Spain is at around 1,500 percent the level of cases compared to when it mandated masks.

After three months of requiring masks, the United Kingdom is at around 1,500 percent more cases despite having one of the highest mask compliance records in Europe.

Belgium required masks shortly after the British did, and now possibly has the highest rate of cases in the world.

Italy had extremely high levels of mask-wearing despite no national mandate. Recently skyrocketing cases finally compelled them to create one of the strictest mask laws in the world, but the results have predictably failed to slow the rise in coronavirus cases. In fact, cases skyrocketed immediately after the mask mandate went into effect.

Similar results have been found in Ireland, Portugal, Israel, and many other countries. No matter how strictly mask laws are enforced nor the level of mask compliance the population follows, cases all fall and rise around the same time.

How about the United States? Americans have proven to be highly compliant with mask wearing, even higher than the Germans.

It is therefore no surprise that the same trends found in Europe are also found in U.S. states. For example, California required masks in June but cases still went up by more than 300 percent and the state remains heavily locked down four months later with still higher cases.

Hawaii suffered one of the most economically devastating lockdowns of all the U.S. states. It was also an early mover on mandating masks both indoors and outdoors, but cases still went up by almost 1,000 percent.

With and without mask mandates, Texas and Georgia followed nearly identical case development.

For those more interested in comparing deaths than cases, we again don’t see a pattern of masks meaningfully helping.

Why Don’t Masks Work?

Why don’t masks work on the general public? For one, if you read the fine print on most consumer masks you will see something along the line of “not intended for medical purposes and has not been tested to reduce the transmission of disease.” Masks can work well when they’re fully sealed, properly fitted, changed often, and have a filter designed for virus-sized particles. This represents none of the common masks available on the consumer market, making universal masking much more of a confidence trick than a medical solution.

If we actually wanted effective masks, then manufacturers should be conducting scientific tests evaluating masks specifically for their ability to reduce the spread of coronavirus. The Food and Drug Administration and CDC should be making recommendations on which masks to use and approving masks based on their scientific efficacy rather than promoting the wrapping of any piece of miscellaneous cloth around your face.

Many powerful institutions have too much political capital invested in the mask narrative at this point, so the dogma is perpetuated.

Effective masks, if they exist, should then be distributed to highly vulnerable groups for use only in rare and extenuating circumstances. There would be little point for the population at large to wear masks all the time because while focused protection may be possible, it is not possible to eradicate the virus at this point or stop its spread.

Our universal use of unscientific face coverings is therefore closer to medieval superstition than it is to science, but many powerful institutions have too much political capital invested in the mask narrative at this point, so the dogma is perpetuated. The narrative says that if cases go down it’s because masks succeeded. It says that if cases go up it’s because masks succeeded in preventing more cases. The narrative simply assumes rather than proves that masks work, despite overwhelming scientific evidence to the contrary.

The narrative further ignores places like Sweden and Georgia, which never required masks in the first place, and it suppresses new scientific evidence if it doesn’t support desired political results, such as data from the world’s only randomized trial investigating if masks actually protect from COVID-19. Even a Nobel laureate has been canceled because his COVID charts and data were found to be undesirable.

History does not bode well for times that politics meddles with science. Martin Kulldorff, a professor at Harvard Medical School and a leader in disease surveillance methods and infectious disease outbreaks, describes the current COVID scientific environment this way: “After 300 years, the Age of Enlightenment has ended.”

In the end, it will be the loss of credibility in our scientific institutions, and the unnecessary division they have sowed among us, for which masks will be remembered.

Yinon Weiss is a tech entrepreneur, a U.S. military veteran, and holds a degree in bioengineering from U.C. Berkeley. Follow him on Twitter.

In Luce tua Videmus Lucem KRK
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Some good news. IIRC, this is the stuff he evil Orange Man was given

Regeneron Antibody Cocktail Cuts COVID-19 Viral Load, 'Medical Visits'
— But number needed to treat is high, and issues of scale-up, cost remain
by Molly Walker, Associate Editor, MedPage Today October 29, 2020


Regeneron's REGN-COV2 monoclonal antibody combination met its primary endpoint and a key secondary endpoint in a phase II/III trial involving high-risk patients with mild to moderate COVID-19, the company said Wednesday.

Compared to patients receiving standard of care plus placebo, patients randomized to combined doses of REGN-COV2, the average daily decrease in viral load through day 7 for patients with a high viral load -- the primary outcome -- was 0.68 log10 copies/mL greater than in patients randomized to placebo (P<0.0001).

Patients also showed a 1.08 log10 greater reduction in the intervention group by day 5 relative to placebo.

Moreover, the two-antibody combination significantly reduced COVID-19-related "medical visits" by 57% through day 29, defined as hospitalizations, emergency room or urgent care visits, or physician office or telemedicine visits.

Notably, though, the vast majority of patients avoided medical visits whether they received the active agents or placebo. Regeneron said 2.8% of patients in combined REGN-COV2 dosing groups and 6.5% of patients in placebo reported a medical visit.

According to one online calculator, those numbers yield a number needed to treat of 27: meaning 27 patients would have to receive the treatment to prevent one medical visit. Regeneron did not provide a breakdown for the composite outcome's individual components.

Infectious Diseases Society of America experts previously commented in general about monoclonal antibody treatments, noting one of the therapy's drawbacks was cost, estimating it would be many thousands of dollars. They also cited the difficulty in scaling up production to treat hundreds of thousands of patients.

Regeneron also said REGN-COV2 treatment led to 72% fewer COVID-19-related medical visits among patients with more than one risk factor (such as older than age 50, cardiovascular, metabolic, lung, liver or kidney disease), but without giving the absolute percentages of patients experiencing the composite outcome.

And most importantly, there was no proof the patients got any better -- Regeneron said "there was no planned formal statistical analysis of symptom alleviation in this analysis."

Previously, the company released descriptive data on 275 patients a month ago; the new data cover an additional 524 patients.

Mean patient age in the trial was about 42, and 53% were women. Half were Hispanic, while 9% were African American. In terms of serology status, 38% were seropositive, 51% were seronegative and 11% were unclear or unknown serology status.

Similar to the earlier descriptive analysis, Regeneron noted patients with a higher viral load and/or no detectable antibodies at baseline derived greater benefit from the intervention, though there was no significant virological or clinical difference with the high-dose (8 grams) group and the low dose (2.4 grams) group.

Examining safety, the manufacturer said the drug was well-tolerated, with a higher proportion of serious adverse events in the placebo group (2.3% placebo, 1.6% low dose REGN-COV2, 0.8% high-dose). Not surprisingly, infusion reactions were more common in the high-dose group (1.5%) versus low dose (0%) and placebo (0.4%).

Regeneron said the phase III trial is continuing in non-hospitalized patients. REGN-COV2 is also being studied in a phase II/III trial for hospitalized patients with COVID-19, a phase III trial for prevention of COVID-19 in household contacts of infected individuals, and as part of the phase III RECOVERY trial in hospitalized patients in the U.K.

The company said it plans to submit these data for publication, and the results were shared with the FDA as part of an emergency use authorization submission already filed.
In Luce tua Videmus Lucem KRK
We're all fucked and going to die. I just want my pill, swallow it now and get it over with.
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Oops, I guess they were wrong all along. How many lives could have been saved. Fauci is a dildo.

Per the AMA:

American Medical Association Rescinds Previous Statement Against Prescription of Hydroxychloroquine to COVID-19 Patients
CHICAGO, IL – The American Medical Association (AMA), in a surprising move, has officially rescinded a previous statement against the use of Hydroxychloroquine (HCQ) in the treatment of COVID-19 patients, giving physicians the okay to return to utilizing the medication at their discretion.

Previously, the AMA had issued a statement in March that was highly critical of HCQ in regards to its use as a proposed treatment by some physicians in the early stages of COVID-19. In addition to discouraging doctors from ordering the medication in bulk for “off-label” use – HCQ is typically used to treat diseases such as malaria – they also claimed that there was no proof that it was effective in treating COVID, and that its use could be harmful in some instances.

However, on page 18 of a recent AMA memo, issued on October 30, (resolution 509, page 3) the organization officially reversed their stance on HCQ, stating that its potential for good currently may supersede the threat of any potential harmful side effects.

So, there we have it. HZQ could not be approved before the election, because President Trump had recommended it. Meanwhile, with an 8o +% reduced risk of having to be admitted to the hospital if administered with Azitromycine and Zinc as soon as testing positive or symptoms occurred, many (70000+) lives could have been saved.

These A-holes should be sued for medical malpractice.
In Luce tua Videmus Lucem KRK
  • wpr
  • Preferred Member
Originally Posted by: KRK 

Oops, I guess they were wrong all along. How many lives could have been saved. Fauci is a dildo.

Per the AMA:
These A-holes should be sued for medical malpractice.

They released this announcement after the election. I am shocked I tell you . Shocked.
This spot is reserved for future use
I wouldn't be surprised, but it looks like the quoted article was updated.

  • KRK
  • Veteran Member
Regarding that Pfizer Vaccine

Don't ask any questions!!! Just line up and take the damn vaccine...DO IT!!!! The state orders you!!!!!

Even though if you are under 40, you have only a 3/1000% chance of dying from this...DO AS WE SAY AND TAKE THE DAMN VACCINE!!


https://twitter.com/i/status/1339750082673954816  MAKE SURE YOU WATCH PAST 30 SECONDS WHEN THE RECIPIENT PASSES OUT

This in addition to other reports including the following:
In Luce tua Videmus Lucem KRK
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Cheesey (9-Feb) : Yup Mucky! I agree! A killer D can make any QB look good.
Mucky Tundra (9-Feb) : Cheesey, Trent Dilfer could win a super with that team and probably had a higher completion percentage against Wash and NO and no floating passes
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Zero2Cool (9-Feb) : Former NFL coach Marty Schottenheimer has passed away,
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Mucky Tundra (9-Feb) : The Patriots and Bucs D allowed 0 TDs in their last two super bowl victories. unreal
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Zero2Cool (8-Feb) : I remembered it and started following in Twitter. Seems the officials were thinking the game was bout them
yooperfan (8-Feb) : Just another fixed game by the NFL. The officiating decided another game. I’m sick of it.🤬
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