I think the starters should play at least the first half and maybe into the third quarter a ways. Treat it like the third preseason game. There is still plenty that they need to work on.
If the Packers and Cardinals are on a collision course for the first round of the playoffs, this game will be very awkward. Neither team will want to waste any good game-planning, and it's quite possible that neither team will want to win the game, as the losing team will have an easier time getting that "edge" going into the playoffs.
This is looking like it could be a pointless game, although I'm certainly not complaining. My main concern will be staying healthy and putting up some decent stats. Donald Driver needs four more yards for 1,000. I bet they throw one of those quick outs to him early in the game so he can get it.