Living in the 49'ers territory the commercial seemed odd.
Unfortunately for the 49'ers they have only one traditional opponent left, the Rams. If you do not understand the Northern and Southern California rivalry you may not understand how it built up. But now, the Rams are in St Louis. It is not the same.
The Falcons for decades in the NFC West are no longer there.
The Cardinals who for decades were in the NFC East are relatively new divisional opponents as is Seattle.
If you think about it, it is rather sad that the 49'ers have lost their rivalries and are attempting to build new ones.