Martha Careful
5 months ago

Scientists Discover Natural Compound That Stops Cancer Progression
By Oregon Health & Science University
March 3, 2025
https://scitechdaily.com/scientists-discover-natural-compound-that-stops-cancer-progression/ 

OHSU scientists, aided by University of Portland undergraduates, discovered that sulfuretin, a plant-derived compound, inhibits an enzyme linked to multiple sclerosis and cancer. The compound may help prevent myelin damage and slow cancer growth. This breakthrough, years in the making, paves the way for further research into sulfuretin’s therapeutic potential.

A discovery led by OHSU was made possible by years of study conducted by University of Portland undergraduates.

Scientists have discovered a natural compound that can halt a key process involved in the progression of certain cancers and demyelinating diseases—conditions that damage the protective myelin sheath surrounding neurons, such as multiple sclerosis (MS).

A study published in the Journal of Biological Chemistry identified a plant-derived flavonoid called sulfuretin as an inhibitor of an enzyme linked to both MS and cancer. The research, conducted in cell models at Oregon Health & Science University, demonstrated that sulfuretin effectively blocked the enzyme’s activity. The next phase of research will involve testing the compound in animal models to evaluate its therapeutic potential, effectiveness, and possible side effects in treating cancer and neurodegenerative diseases like MS.

A Potentially Wide-Reaching Treatment
“We think this is a drug that could have impact in a lot of different areas,” said Larry Sherman, Ph.D., professor in the Division of Neuroscience at OHSU’s Oregon National Primate Research Center.

The researchers found that sulfuretin, along with a pair of synthetic compounds that were also tested in live cells, inhibited the activity of a particular type of enzyme known as a hyaluronidase, which naturally degrades hyaluronic acid. That’s important because when hyaluronic acid is broken down into fragments, it is known to cause problems in at least two ways:

Forestalls myelin repair: It prevents the maturation of oligodendrocytes, which are cells that produce myelin. Myelin is the protective sheath covering each nerve cell’s axon — the threadlike portion of a cell that transmits electrical signals between cells. Damage to myelin is associated with MS, stroke, brain injuries, and certain forms of dementia. In addition, delay in myelination can affect infants born prematurely, leading to brain damage or cerebral palsy.
Allows cancer cells to proliferate: In cancerous tumors, hyaluronidase activity can allow cancer cells to proliferate unchecked by normal cellular death. “Now we have an inhibitor that could actually stop that,” said Sherman, who is also a professor of cell, developmental, and cancer biology in the OHSU School of Medicine.

The new research focuses on inhibiting a specific type of hyaluronidase known as cell migration-inducing and hyaluronan-binding protein, or CEMIP.

In addition to MS and cancer, CEMIP is implicated in a range of disorders, including osteoarthritis, skin infections, brain injury caused by heavy alcohol use, and possibly other neurodevelopment disorders, including Alzheimer’s disease. The study indicates its activity appears to be inhibited by sulfuretin.

Molecules in flowers
The discovery came after years of undergraduates painstakingly screening plant compounds in the lab of co-author Angela Hoffman, Ph.D., a longtime and now-retired professor of chemistry at the University of Portland.

“Over the years, her students have been grinding up these flowers, extracting molecules, and testing to see if any of them blocked hyaluronidase activity,” Sherman said. “Finally, a couple of years ago, they found a compound that was promising.”

Alec Peters, a graduate student in Sherman’s lab at OHSU, found that this compound blocked CEMIP activity in a tumor cell line and in oligodendrocyte progenitor cells. Oligodendrocytes generate myelin.

Hoffman, a nun and chemistry professor who earlier this year retired from the University of Portland after 35 years to lead her convent, began collaborating with Sherman a decade ago. Over that time, she said, hundreds of undergraduate students worked on breaking down dozens of plants to their molecular essence and then testing to see whether any of the compounds worked to neutralize CEMIP.

The new publication validates the students’ diligent work over many years, she said.

“Directing the students to be able to do this kind of research helps them in their careers,” Hoffman said. “This discovery could be useful for Alzheimer’s or other neurodegenerative conditions. As long as the underlying problem relates to hyaluronic acid being broken apart, this could be helpful for people.”

Neat!!! Promising!!!!
Go Packers!!!!
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Mucky Tundra (3h) : Ugh this trade happened right as my shift started and it's killing me
Zero2Cool (3h) : Parsons wore 23 in high school.
Zero2Cool (3h) : Packers just cost Lions more money with Hutchinson too huh
Zero2Cool (5h) : That is fair by me.
buckeyepackfan (5h) : Kenny Clark is the player, 2 1st rnd picks
Zero2Cool (5h) : umm... what?
wpr (5h) : I am stunned
Mucky Tundra (5h) : RICKEY SCOOPS WAS RIGHT AGAIN!!!
Mucky Tundra (5h) : ITS HAPPENING
buckeyepackfan (5h) : DEAL IS DONE
buckeyepackfan (5h) : MICAH IS COMING TO GREEN BAY!!!!!!!!!
wpr (12h) : Me do-ed it gooderly,
Zero2Cool (28-Aug) : Bahah, I was like WTF why isn't anyone posting on PP.com ... oops no one has permissions
dfosterf (27-Aug) : tell her I reckon
dfosterf (27-Aug) : Micah Robinson cut. Probable PS player tomorrow. Has to call mom back and t
Zero2Cool (27-Aug) : New site so much better. Might make switch and deal with it.
dfosterf (27-Aug) : Mecole Hardman to our practice squad
dfosterf (27-Aug) : Nick Nieman from Texans our 5th linebacker. Special teams signing
TheKanataThrilla (27-Aug) : Looks like we signed Clayton Tune as QB3
wpr (27-Aug) : TKT people lose their minds over QB3. Point is almost none of them are ready that's why they are on the PS and other teams don't take them.
TheKanataThrilla (27-Aug) : Unfortunately he doesn't seem ready to be an emergency QB.
TheKanataThrilla (27-Aug) : As a Canadian and a follower of Canadian University football. I am rooting for him
dfosterf (27-Aug) : I bet a lot of us will follow the Taylor Elgersma journey with interest. Personally, got a Kurt Warner vibe goin' on. I like him
TheKanataThrilla (27-Aug) : Not sure if either will be claimed though.
TheKanataThrilla (27-Aug) : Tune or Hooker would make sense
dfosterf (27-Aug) : Clayton Tune cut by the Cards? Don't know if that's the guy, we shall see
TheKanataThrilla (27-Aug) : Per Bill Huber, the Packers will not be bringing back Taylor Elgersma or Sean Clifford on the practice squad, so a new third quarterback
Mucky Tundra (27-Aug) : Schefter must have deleted his tweet
dfosterf (27-Aug) : Hopefully Jerry reaches under the seat cushions and ashtrays of his jet and scrapes up the 45 million apr and spares us further nonsense
dfosterf (27-Aug) : Have to admit the PO'd Cowboy fan videos would be fun to watch. Problem with draft picks is half their fanbase barely knows what that is
beast (27-Aug) : I think Cowboys fans are ready to get their pitch forks and burning sticks if Jerry were to trade Micah
dfosterf (27-Aug) : If Jerry traded Micah to GB, here in northern Va. they would have to quick build yet another data center to handle the internet hate traffic
Zero2Cool (27-Aug) : its signing and trades that you don't hear about, other then announced
Zero2Cool (27-Aug) : If you hear rumors about Packers sign or trade, won't happen. Not how they work
dfosterf (27-Aug) : 19 players in a contract year. Jones called loss to us worst loss in Cowboy history. Forget Parsons trade. Not happenin' Cap'n
packerfanoutwest (27-Aug) : The Packers, meanwhile, are the youngest team in the league for the third consecutive year.
dfosterf (27-Aug) : That it was darkest before the dawn in Bengals and Commanders before they got deals done
Zero2Cool (27-Aug) : what is Schefter saying?
dfosterf (27-Aug) : He was getting Dorito infusion therapy
dfosterf (27-Aug) : He's outta shape. Why, just the other day I saw him splayed out on the trainers table
Mucky Tundra (27-Aug) : Parsons has followed Rasheed Walker on Twitter. Quite the choice
Mucky Tundra (27-Aug) : Kuhn is a former player who works for the team, if somethings going down, he would be close to it
Mucky Tundra (27-Aug) : @kuhnj30 Micah Freaking Parsons
Mucky Tundra (27-Aug) : A LOT of buzz on the Bird App regarding Parsons; even Schefter is saying it's serious
dfosterf (26-Aug) : *Orzech*
dfosterf (26-Aug) : Orzich long snapper 3 yr extension
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