Martha Careful
2 months ago

Scientists Discover Natural Compound That Stops Cancer Progression
By Oregon Health & Science University
March 3, 2025
https://scitechdaily.com/scientists-discover-natural-compound-that-stops-cancer-progression/ 

OHSU scientists, aided by University of Portland undergraduates, discovered that sulfuretin, a plant-derived compound, inhibits an enzyme linked to multiple sclerosis and cancer. The compound may help prevent myelin damage and slow cancer growth. This breakthrough, years in the making, paves the way for further research into sulfuretin’s therapeutic potential.

A discovery led by OHSU was made possible by years of study conducted by University of Portland undergraduates.

Scientists have discovered a natural compound that can halt a key process involved in the progression of certain cancers and demyelinating diseases—conditions that damage the protective myelin sheath surrounding neurons, such as multiple sclerosis (MS).

A study published in the Journal of Biological Chemistry identified a plant-derived flavonoid called sulfuretin as an inhibitor of an enzyme linked to both MS and cancer. The research, conducted in cell models at Oregon Health & Science University, demonstrated that sulfuretin effectively blocked the enzyme’s activity. The next phase of research will involve testing the compound in animal models to evaluate its therapeutic potential, effectiveness, and possible side effects in treating cancer and neurodegenerative diseases like MS.

A Potentially Wide-Reaching Treatment
“We think this is a drug that could have impact in a lot of different areas,” said Larry Sherman, Ph.D., professor in the Division of Neuroscience at OHSU’s Oregon National Primate Research Center.

The researchers found that sulfuretin, along with a pair of synthetic compounds that were also tested in live cells, inhibited the activity of a particular type of enzyme known as a hyaluronidase, which naturally degrades hyaluronic acid. That’s important because when hyaluronic acid is broken down into fragments, it is known to cause problems in at least two ways:

Forestalls myelin repair: It prevents the maturation of oligodendrocytes, which are cells that produce myelin. Myelin is the protective sheath covering each nerve cell’s axon — the threadlike portion of a cell that transmits electrical signals between cells. Damage to myelin is associated with MS, stroke, brain injuries, and certain forms of dementia. In addition, delay in myelination can affect infants born prematurely, leading to brain damage or cerebral palsy.
Allows cancer cells to proliferate: In cancerous tumors, hyaluronidase activity can allow cancer cells to proliferate unchecked by normal cellular death. “Now we have an inhibitor that could actually stop that,” said Sherman, who is also a professor of cell, developmental, and cancer biology in the OHSU School of Medicine.

The new research focuses on inhibiting a specific type of hyaluronidase known as cell migration-inducing and hyaluronan-binding protein, or CEMIP.

In addition to MS and cancer, CEMIP is implicated in a range of disorders, including osteoarthritis, skin infections, brain injury caused by heavy alcohol use, and possibly other neurodevelopment disorders, including Alzheimer’s disease. The study indicates its activity appears to be inhibited by sulfuretin.

Molecules in flowers
The discovery came after years of undergraduates painstakingly screening plant compounds in the lab of co-author Angela Hoffman, Ph.D., a longtime and now-retired professor of chemistry at the University of Portland.

“Over the years, her students have been grinding up these flowers, extracting molecules, and testing to see if any of them blocked hyaluronidase activity,” Sherman said. “Finally, a couple of years ago, they found a compound that was promising.”

Alec Peters, a graduate student in Sherman’s lab at OHSU, found that this compound blocked CEMIP activity in a tumor cell line and in oligodendrocyte progenitor cells. Oligodendrocytes generate myelin.

Hoffman, a nun and chemistry professor who earlier this year retired from the University of Portland after 35 years to lead her convent, began collaborating with Sherman a decade ago. Over that time, she said, hundreds of undergraduate students worked on breaking down dozens of plants to their molecular essence and then testing to see whether any of the compounds worked to neutralize CEMIP.

The new publication validates the students’ diligent work over many years, she said.

“Directing the students to be able to do this kind of research helps them in their careers,” Hoffman said. “This discovery could be useful for Alzheimer’s or other neurodegenerative conditions. As long as the underlying problem relates to hyaluronic acid being broken apart, this could be helpful for people.”

Neat!!! Promising!!!!
Go Packers!!!!
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Mucky Tundra (22h) : Also notes he’s playing with more confidence.
Mucky Tundra (22h) : @AndyHermanNFL MLF says there was a time last year where Cooper was at 220 pounds. Now he’s at 240 and still flying around.
Mucky Tundra (22h) : And don't even get me started on Frank Caliendos "impersonations"
Mucky Tundra (22h) : I got tired of them being circle jerks with them overlaughing at each others jokes.
Zero2Cool (22h) : It used to be must watch TV for me. now it's "meh" maybe to hear injury update
Mucky Tundra (22h) : I haven't watched the pregame shows in years and I don't feel like I've missed a thing
Zero2Cool (22h) : Love says knee affected him all season, groin injury didn't help matters.
Zero2Cool (22h) : I used to enjoy him on FOX Pregame. Now it's like a frat party of former Patriots.
Zero2Cool (22h) : LaFleur on Watson: “Christian is doing outstanding. I would say he’s ahead of schedule.”
Martha Careful (23h) : Bradshaw is a dumb ass cracker. I am so tired of his "aw shucks" diatribe. He should shrivel up and go away.
buckeyepackfan (28-May) : He wad all butt hurt because Aaron duped the media saying he was immunized.
buckeyepackfan (28-May) : Bradshaw needs to retire. He's been ripping on Rodgers ever since the covid crap. He was all hury
Zero2Cool (28-May) : Terry Bradshaw doesn't want Rodgers in Pittsburgh lol wow
Zero2Cool (27-May) : one day contract, which he also feels is pointless, but if Packers came to him, he would
packerfanoutwest (27-May) : Aaron Rodgers talks possibility of retiring with Packers, just another rumor
dfosterf (27-May) : Go watch 2001
Zero2Cool (26-May) : 1984
dfosterf (26-May) : That movie sent a chill through many. 1968.
dfosterf (26-May) : "Open the pod bay doors, HAL"
buckeyepackfan (25-May) : Haven't we all seen thus movie? It doesn't end well!! Lol
Zero2Cool (25-May) : lol Anthropic’s new AI model turns to blackmail when engineers try to take it offline
dfosterf (25-May) : Claude Opus 4
dfosterf (25-May) : AI system resorts to blackmail when its developers threaten to take it offline
beast (22-May) : Colts Owner Jim Irsay has passed away
Zero2Cool (21-May) : Well, emailing should work now. After not working for almost a year. Oops.
Zero2Cool (21-May) : Brotherly Shove did not get enough votes.
Zero2Cool (20-May) : lol our email hasn't worked in months. 7 pages of unverified users
Zero2Cool (20-May) : MySpace Screaming Lord Byron ... Brett Favre.
Zero2Cool (19-May) : Packers have signed first-round pick Matthew Golden, leaving second-round tackle Anthony Belton as their only unsigned draft pick
beast (19-May) : Supposedly he has to take his image, and name off of it... but otherwise could keep selling wine if he wanted to.
Zero2Cool (19-May) : he giving up his win business?
beast (19-May) : Speaking of Woodson, sounds like he'll be a minority owner (0.1%) of the Browns
Mucky Tundra (15-May) : Zero, regarding Woodson, that'd why I find the timing with Williams peculiar
dfosterf (15-May) : Ryan Hall y'all does a great job of tracking thesr
Zero2Cool (15-May) : Fear not!! I planned to do 33mi bike ride tomorrow morning, so ... yeah
Zero2Cool (15-May) : We got some dark clouds and nasty winds right bout now.
Zero2Cool (15-May) : Madison they had hail 4pm.
dfosterf (15-May) : Sure looks like these tornadoes are headed towards Green Bay
Zero2Cool (15-May) : Woodson of Charles fame was reluctant and then loved it. that didn't really come out until post career
Mucky Tundra (15-May) : IE "We bought into the Bears and they let us down, we have no choice to seek alternatives"
Mucky Tundra (15-May) : Or that Williams and his family are preparing an exit ramp if they don't like how things are going in a few years
Mucky Tundra (15-May) : Either Williams thought it would make him look good (reluctant but then embraces the city and franchise)
Mucky Tundra (15-May) : I can only assume that the Williams camp agreed to cooperate with that article tells me 2 things
dfosterf (15-May) : Ya. They are in a great mood
Zero2Cool (15-May) : I should visit again
dfosterf (15-May) : ChiCity Sports entering freakout mode due to Caleb and his dad not wanting him to go there
Zero2Cool (15-May) : "He's looking really good out there," Derrick Ansley said of Kalen King. Adds that he's been playing inside and out.
Zero2Cool (15-May) : Him saying he doesn't have one to give haha
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