I drank a lot more when I was younger.
But apart from some occasions in high school and college where I drank primarily to get drunk and engaged in too many "drinking games" before driving, I don't regret any of it. Not the beer, not the (occasional for me) wine, not the cocktails and not the straight bourbon, tequila, or scotch. Not the "social drinking," not the "with meals drinking," and not the occasional drunkenness (Super Bowl 31, the night after I defended my dissertation, etc.). Nor do I apologize for having a well-stocked liquor cabinet (many of the bottles still there 5-10 years since they were first opened or for having a few bottles of port that won't be ready to open for another 5-10 years.
And the fact that those choices are part of the reason I am now type II diabetic, way too obese, and probably will die well before the average American, doesn't change that.
I regret some stupid things I did when young, just as I regret -- really regret -- some really stupid financial and other life decisions I've made in each decade of my adult life. And I really, really, really regret how I have spent most of my life doing things that must have truly disgusted my Lord God. I really, really regreat how I have focused so much of my life chasing the winds of self-absorbtion and pursuing various values of the world rather than living for His glory in all things. I regret how I have squandered decades of His gifts to me. I regret how I have failed in following the first Great Commandment; and I have a list of personal apologies for violations of the second that I will never be able to make because the people to whom those apologies are owed are dead or their whereabouts unknown.
Insofar as my above-average lifetime alcohol consumption has been part of my personal history of idolatry of self and of the world's false gods, then, yes, I regret that consumption. But because it has been biologically bad for me? No.
No regrets at all.
And do not be conformed to this world, but be transformed by the renewing of your mind, that you may prove what is that good and acceptable and perfect will of God.
Romans 12:2 (NKJV)