He is of Ojibway descent, one eighth, meaning one great grandparent was Ojibway.[4] He discovered as an adult that his paternal grandfather was Creole (of African and French descent).

He considers himself a political independent, and is a practicing Roman Catholic. LeDuff is also a member of the Sault Ste. Marie Chippewa tribe of Michigan.

The preface of US Guys includes this quote on Leduff's view of the American male:

The American man has been taught that while it is better to avoid a fight; that honor cannot always be defended with reason. He should never admit fear. He should always strive to put the blade in his adversary’s chest, not his back. An American man should know how to load and fire a gun. He should know how to ride a horse, bet on a horse, bet on the stock market, and bet on the cards. A good man should know a woman’s body and know how to please her. His woman, in turn, should never speak anything but well of him in public. An American man should have been raised in the church, rejected the church and eventually found virtue in the church.

The American man should be educated. He should work. He should honor his debts and live within his means. He should be able to recite poetry and have bits of true philosophy at his fingertips. He should be able to play an instrument and know how to help a rose grow. An American man should know how to dress and speak his language well. He should be handy and mechanically inclined and yet his nails must be clean. A man should have children, and at some point his children should reject him. And in the course of his life, a man’s children should return and find virtue in him.

This is what an American man should be. Of course, no such man has ever existed, and no man probably ever will.