I'd go out and spent some money on one bitchin' hairpiece. That way, I could get on the sidelines, instead of up in a boot, without the fear of my combover being uncovered.
And yes, I'd go full anti-run, as well. I reckon the Vikings are the only team in the entire league that I'd play purely on the run and let them try to beat me through the air.
I'd try to bring more than 4 on, at least, 60% of the plays. Something I certainly WOULDN'T do, is let Matthews play spy 50% of the time. Next to that, they don't have any real receivers with Harvin gone, and it has shown, with nearly no passes going to that WR group. If it was up to me, we'd be playing high pressure, blitz some guys (mainly run blitzes, but even Hawk can get to the QB, eventually) and play agressive in the secondary.
I know, it'd be a bit hard to get Shields in on the action in that case, but for as far as I'm concerned, you could play a base with Williams, Hayward and Woodson against this team and still have the upper hand. Just have those three jam receivers at the line, with either Hawyard or Woodson on Ponder's security blanket, Rudolph.