I think the 2-4-5 provides more to work with schematically, but given our injury situation it may not be a bad idea. My only worry would be overextending the d-line. They can get a decent rotation when using the 2-4-5. That said, no single formation is going to be a cure all -- not that OP is suggesting it.
I don't know enough about defenses and gap control to actually speak to the 3-3-5, but I know a lot of 3-4 teams fit well with it. My understanding is that it does put a lot of pressure in the MLB, who occupies more of a 4-3 ILB responsibility. The OLBs aren't designated speed rushers either. An advantage of the 2-4-5 is the LBs playing so close to the line, rushing off the edge.
All that said, I wouldn't mind to see some tinkering -- though it is nice to stick in a formation and give a lot of different looks from it, which is what we've done with the 2-4-5. I wish Matthews wasn't banged up.
William Henderson didn't have to run people over. His preferred method was levitation.
"I'm a reasonable man, get off my case."