I think this game comes down to does the Packers pass rush get to Eli before Eli gets the ball to an open WR or not.
Like most I was worried about the Packers ability to cover... but looking at the Giants schedule this game is different than most of their others. First of, the Packers don't have a defense like the Vikings.... but at the same point, the Giants beat the Cowboys and Saints... which I've heard (but can't confirm) that both have been having huge problems with getting consistent/good pass rush... so I would hope that the Packers have a better pass rush than them.
That just leaves the Redskins game to compare... and Eli did great with 25/38 passing (65.78%) and 350 yards... but also horrible with 2 INTs and 2 fumbles (which the Giants recovered both, but still).
And other than the Viking beat down all their games have been within 3 points. And some have said their Cowboys win and Redskins loss, both should have gone the other way.
Eli had 3 TDs and 1 INT against the Cowboys. Since then, he has had 1 TD and 3 INTs.
Eli is a risk taker, with the gunslinger mentality. If you can shake Eli into throwing some passes early, the DBs will have chances to make INTs.