Although I beleive the Packers will win this one, let's play the "devils advocate" here for a moment.
What the Lions could/can do to beat the Packers
On Defense:
Biggest key will be stopping the Packers run game.
Lions are one of the few teams that can stop the run while playing two safeties deep in coverage.
Stopping the run with minimal players, and freeing up more for trying to stop the Packers passing game, which is where the Packers rule. That and limit Jordy Nelson, contain him.
Limit the blitzes on Rodgers and rush with four.
On Offense:
Reggie Bush.
The Packers will have to deal with his speed and pass catching skills as well.
Packers' linebackers and safeties have vulnerabilities on defense because of their hesitation.
The biggest weapon against hesitation is speed, and Reggie still has that.
That and if Matthew Stafford decides to play up to his capabilties (which sometimes fails him), he can do some damage.
And as to the Lions as a whole, and this is huge for them, it has been a very long time since they have anything to play for.
They do now and this is the chance for some huge redemption for them.
Do not discount that motivation and impact.
Latest Lions injury post:
RB Joique Bell (Achilles) - Limited in practice
WR Calvin Johnson (ankle) - Did not practice
DT Nick Fairley (knee) - Did not practice
CB Mohammed Seisay (hamstring) - Fully practiced
I am chosen by many but taken by no one.